Paul Thompson's Research Publications
Unfolding the Human Hippocampus with High-Resolution Structural
and Functional MRI
The New Anatomist [Invited Paper; submitted, November 2000]
Michael M. Zeineh 1, Stephen A. Engel2, Paul M. Thompson 3,
Susan Y. Bookheimer 1
1Ahmanson-Lovelace Brain Mapping Center, UCLA
2UCLA Department of Psychology
3Laboratory of Neuro Imaging, Department of
Neurology, Division of
Brain Mapping, UCLA School of Medicine, Los Angeles, California
90095
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ABSTRACT
The hippocampus is a region of the brain that is crucial to memory function. Functional neuroimaging
allows for the noninvasive investigation of the neurophysiology of human memory by observing changes in
blood flow in the brain. We have developed a technique that employs high-resolution functional magnetic
resonance imaging (fMRI) in conjunction with cortical unfolding to provide activation maps of the
hippocampal region that surpass in anatomic and functional detail other methods for in vivo brain mapping
of the medial temporal lobe. We explain the principles behind this method and illustrate its application to
a novelty encoding paradigm.
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Key Words: brain imaging; magnetic resonance imaging; functional MRI; medial temporal lobe;
hippocampus; memory; cortical unfolding; flat maps
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Contact Information
Mail:
Paul Thompson, Ph.D.
Assistant Professor of Neurology
Laboratory of Neuro Imaging and Division of Brain Mapping
710 Westwood Plaza, UCLA School of Medicine
Westwood, Los Angeles CA 90095-1761, USA.
E-mail:
thompson@loni.ucla.edu
Tel: (310)206-2101
Fax: (310)206-5518